From the National Institute on Deafness and other Communication Disorders.

نویسنده

  • J B Snow
چکیده

How the results of this project will benefit society: Abnormalities in the sense of smell have particular clinical relevance for patients with Alzheimer’s disease (AD), in whom deficits of smell identification and discrimination arise early in the course of illness, and often before the emergence of overt cognitive symptoms such as memory loss. Given the early accumulation of Alzheimer’s pathology in olfactory limbic regions of the brain, human olfactory imaging techniques should be a highly sensitive method for assessing limbic dysfunction in this neurodegenerative disorder, opening up the possibility of developing a noninvasive imaging biomarker to predict which individuals are at risk for developing AD. Ultimately, with the emergence of novel therapeutic and preventative strategies for AD on the horizon, the need for reliable diagnostic tools, particularly for pre-symptomatic stages, will become increasingly critical, and the proposed imaging research in healthy subjects should provide important information toward this end.

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عنوان ژورنال:
  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

دوره 106 3  شماره 

صفحات  -

تاریخ انتشار 1992